fetal akinesia / hypokinesia sequence

fetal akinesia sequence (FAS) is an event that can occur with a lack of fetal movement (fetal akinesia). This results in


The esimated prevalence is at ~ 1 in 3000 births.


In utero fetal movement in considered essential for normal fetal growth. In FAS intra uterine immobility is thought to be triggered by a number of factors which include

  • central or peripheral neuropathic process(es)
    • congenital or secondary to in utero infective insult
  • congenital myopathies
    • glycogen storage diseases (particularly types IV and VII)
    • fetal aceytylcholine receptor subunit mutations
    • Nemaline myopathy
  • intra uterine exposure to immobilizing substances
  • connective tissue or cutaneous conditions (restrictive dermatopathy) limiting fetal movement
  • external movement limiting factors

See also

Siehe auch:
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