Octreotide scintigraphy

Octreotide scintigraphy uses In-labeled octreotide which is a somatostatin analog; it is also known as an Octreoscan, a brand name for In-labeled pentetreotide; pentetreotide is a DTPA-conjugated form of octreotide, originally manufactured by Mallinckrodt Nuclear Medicine LLC, which now forms part of Curium).

The radiotracer is characterized by a high affinity of bond with the somatostatin receptor 2 (SST2). It penetrates inside the cell by endocytosis, first held by lysosomes and then transferred to the nucleus .

It is particularly useful for assessment of neuroendocrine tumors, and the Krenning Score is used to grade these, most commonly for peptide receptor radionuclide therapy (PRRT) planning.

Examples include:

Certain non-neuroendocrine tumors can also show uptake in an octreoscan. Examples include:

Also, certain autoimmune or granulomatous diseases (for example sarcoidosis) may occasionally show octreotide uptake by overexpression of somatostatin receptors.

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