osteomalacia

Osteomalacia is bone softening due to insufficient mineralization of the osteoid secondary to any process that results in vitamin D deficiency or defects in phosphate metabolism:

  • high remodeling rate: excessive osteoid formation with normal/little mineralization
  • low remodeling rate: normal osteoid production with diminished mineralization

Epidemiology

Because of the many causes of osteomalacia worldwide, the epidemiology is highly variable .

Clinical presentation

Patients with osteomalacia may be asymptomatic or present with bone pain/tenderness and/or muscular weakness.

Pathology

Etiology
Markers
  • 25(OH)D: decreased
  • serum calcium: slightly decreased / normal
  • urinary calcium: decreased
  • serum phosphorus: decreased
  • serum alkaline phosphatase: elevated
  • serum parathyroid hormone: elevated

Radiographic features

Musculoskeletal

There can be variable appearances dependent on the cause:

Siehe auch:
und weiter: