Focal hypodense hepatic lesions on non-enhanced CT (differential)

Focal hypodense hepatic lesions on a non-contrast CT scan can result from a number of pathological entities, including:

• neoplasms
  • benign
    • hepatic hemangioma
    • adenoma
    • biliary hamartoma: von Meyenberg complexes
  • malignant
    • hepatoma/hepatocellular carcinoma (HCC)
    • hepatic lymphoma
    • hepatic haemangiosarcoma
    • intrahepatic cholangiocarcinoma
    • metastasis
• focal nodular hyperplasia
• Focal steatosis
• cyst(s)
  • benign epithelial cyst: simple hepatic cyst
  • polycystic liver disease
  • hepatic hydatid infection
  • von Hippel-Lindau disease
• hepatic abscess
  • pyogenic
  • fungal
  • amoebic
• vascular
  • infarction
  • laceration
  • hematoma (old)
• biliary tree dilatation
  • Caroli disease
  • choledochal cyst