macrocephaly

Macrocephaly is a clinical and radiological term that refers to a generalized increase in the size of the cranial vault.

Terminology

This slightly differs from the term megalencephaly which means an increase in the size of the brain parenchyma.

Epidemiology

• content pending

Clinical presentation

• content pending

Pathology

In an infant it can result from a wide range of causes:

• congenital hydrocephalus: this, in turn, can result from a multitude of causes
• hydranencephaly: the choroid still forms CSF
• subdural fluid collection
• neurofibromatosis type 1
• achondroplasia
• hypochondroplasia
• thanatophoric dysplasia
• tuberous sclerosis complex
• metabolic storage diseases, e.g. mucopolysaccharidoses
• Alexander disease
• Greig syndrome
• Gorlin-Goltz syndrome
• Ruvalcaba syndrome
• Canavan disease
• cranio-cerebello-cardiac (CCC) syndrome
• Sotos syndrome
• Bannayan–Riley–Ruvalcaba syndrome (BRRS)

Radiographic features

Some define the condition on skull radiography when the head circumference is more than 2 standard deviations above the mean or exceeds the 97percentile by at least 0.5 cm .

See also

• benign enlargement of the subarachnoid spaces in infancy as a benign cause of macrocephaly
• fetal macrocephaly

Siehe auch:

• Tuberöse Sklerose
• Neurofibromatose Typ 1
• Achondroplasie
• Gorlin-Goltz-Syndrom
• Thanatophore Dysplasie
• Mukopolysaccharidose
• Morbus Alexander
• Morbus Canavan
• Greig-Syndrom
• Sotos-Syndrom
• Megaloenzephalie
• kongenitaler Hydrozephalus
• benign enlargement of the subarachnoid spaces in infancy
• Hydranenzephalie

und weiter:

• Aquäduktstenose
• neuroradiologisches Curriculum
• fetale Hirntumoren
• bilateral megalencephaly
• Mukopolysaccharidose Typ I-H
• Clark-Baraitser-Syndrom
• benigne Erweiterung des Subarachnoidalraums bei Kindern
• kongenitale Aquäduktstenose
• bannayan zonana syndrome
• Johnson-Syndrom
• tay sachs disease
• kortikale Malformation
• Weaver-Syndrom
• Fukosidose