In a strict anatomical sense, it contains three paired nuclei that together comprise the corpus striatum:
Functionally, two additional nuclei are also part of the basal ganglia:
Whilst very widely used in English, the term 'basal ganglia' is actually a misnomer, as a ganglion is a collection of nerve cell bodies outside of the central nervous system. The equivalent within the central nervous system is termed 'nucleus', as reflected in the official term for the basal ganglia in the Terminologia Anatomica, 'nuclei basales', the English translation of which is 'basal nuclei'.
This is also illustrated by the name of each individual basal nucleus, e.g. caudate nucleus, lentiform nucleus, subthalamic nuclei, etc.
The basal ganglia are normally isodense/isointense to the cortex. Because the globus pallidus has more myelin content compared with the putamen, it usually appears slightly more hypointense on T2WI, GRE, and SWI images. Age-related calcium deposition in the globus pallidus initially results in increased T1 signal intensity and subsequently, when calcification exceeds 40%, signal loss in all sequences. Aging with consequent iron deposition in the putamen results in a gradual decrease of T2/T2*/SWI signal intensity in the putamen. This is more pronounced in the 8 or 9 decade of life.
- basal ganglia calcification
- Parkinson disease
- Huntington disease
- Hallervorden-Spatz syndrome
- central pontine myelinolysis
- gliomatosis cerebri
- cerebral microhemorrhage