Bronchogene Zyste

Bronchogenic cysts are congenital malformations of the bronchial tree (a type of bronchopulmonary foregut malformation). They can present as a mediastinal mass that may enlarge and cause local compression. It is also considered the commonest of foregut duplication cysts.


Bronchogenic cysts are rare congenital lesions accounting for only 5-10% of pediatric mediastinal masses . The incidence of mediastinal cysts is equal between the sexes whereas intrapulmonary cysts are reported to have a male predilection .

Clinical presentation

In many instances, bronchogenic cysts are asymptomatic and are found incidentally when the chest is imaged . When large, mass effect may result in bronchial obstruction leading to air trapping and respiratory distress. An alternative presentation may occur when the cyst becomes infected.


Bronchogenic cysts form as a result of abnormal budding of the bronchial tree during embryogenesis (between 4-6 weeks) , and as such, they are lined by secretory respiratory epithelium (cuboid or columnar ciliated epithelium) . The wall is made up of tissues similar to that of the normal bronchial tree, including cartilage, elastic tissues, mucous glands, and smooth muscle .

They do not usually communicate with the bronchial tree and are therefore typically not air-filled. Rather, they contain fluid (water), variable amounts of proteinaceous material, blood products, and calcium oxalate . It is the latter three components that result in increased attenuation mimicking solid lesions. They are rarely multiple.


They can occur in the mediastinum or be intrapulmonary. The most common location is the middle mediastinum (65-90%). The distribution of locations can be quite varied:

  • mediastinal (~70%) 
    • usually does not communicate with the tracheobronchial tree
    • subcarinal, right paratracheal and hilar locations most common 
    • approximate incidence includes
      • carinal area: ~50%
      • paratracheal area: ~20%
      • oropharyngeal wall: ~15%
      • retrocardiac area: ~10% 
  • parenchymal (intrapulmonary)
    • typically perihilar
    • predilection for lower lobes
  • other uncommon locations
    • neck
    • cutaneous
    • pericardium
    • extending across the diaphragm and appearing dumb-bell shaped
    • retroperitoneal : tend to be in a subdiaphragmatic or peripancreatic distribution, usually to the left of the midline

Radiographic features

Although bronchogenic cysts are usually fluid-filled, occasionally a communication may develop following infection or intervention, resulting in an air-filled cystic structure +/- an air-fluid level .

Plain radiograph

The cysts usually appear as soft-tissue density rounded structures, sometimes with compression of surrounding structures. Occasionally such compression can lead to air-trapping and a hyperlucent hemithorax . As the cysts may contain calcium oxalate, dependent layering of calcific density material (milk of calcium) may on occasion be seen .


Typically appear as well-circumscribed spherical or ovoid masses of variable attenuation with variable fluid composition explaining the different CT attenuations observed.

Approximately 50% are fluid density (0-20 HU), however, a significant proportion is of soft tissue density (>30 HU) or even hyperattenuating to surrounding mediastinal soft tissues . The degree of CT attenuation often depends on the amount of internal proteinaceous content . CT is better able to detect calcium oxalate (milk of calcium) layering dependently .

There is no solid contrast enhancement.


Sometimes performed for confirmation, especially with atypical cases. Mostly homogeneous .

  • T1:
    • variable signal intensity, from low (similar to fluid) to high (due to protein content)
    • fluid-fluid level has also been reported, attributed to the layering of variable fluid content
  • T2: 
    • usually high signal intensity due to fluid content

Treatment and prognosis

The choice of treatment is somewhat controversial. Some authors advocate surgical excision of all cysts given their tendency to become infected or rarely, to undergo malignant transformation . Increasingly, these lesions are treated with transbronchial or percutaneous aspiration under CT guidance to both confirm the diagnosis and to treat them. Small lesions can be followed, however, they do have a tendency to increase in size over time, sometimes rapidly .


Differential diagnosis

General imaging differential considerations for uncomplicated cysts include:

If complicated, e.g. with infection or hemorrhage, also consider:

See also

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