breast carcinoma
Breast neoplasms consist of a wide spectrum of pathologies from benign proliferations, high-risk lesions, precursor lesions, to invasive malignancies. This article provides an overview for radiologists, with a focus on breast cancer. For a summary article for medical students and non-radiologists, see breast cancer (summary).
Epidemiology
Breast cancer is the most common nonskin malignancy in women. In the affluent populations of North America, Europe, and Australia, 6% of women develop invasive breast cancer before age 75, compared to a 2% risk in developing regions of Africa and Asia . The difference has been attributed to risks associated with a Westernized lifestyle, including high-calorie diet rich in fat and protein and physical inactivity .
Risk factors
- increasing age
- reproductive lifestyle factors increasing unopposed estrogen load
- early menarche
- nulliparity, infertility, or, if parous, few children with late age at first delivery
- lack of breastfeeding
- late menopause
- unopposed estrogen hormone replacement therapy
- personal history of breast cancer or a high risk breast lesion
- first degree relative with breast cancer
- genetic mutations
- thoracic radiation therapy
- alcohol consumption
Pathology
Classification
The main pathological classification of breast neoplasms is published by the World Health Organization: WHO classification of tumors of the breast.
The vast majority of breast cancers are adenocarcinomas (99%). The most common types are :
- invasive carcinoma of no special type (ductal carcinoma not otherwise specified): 40-75%
- ductal carcinoma in situ: 20-25%
- invasive lobular carcinoma: 5-15%
Categories of benign epithelial neoplasms include:
Nonepithelial malignancies are uncommon and include:
Immunophenotype
Three molecular biomarkers are routinely evaluated in invasive breast cancers because they have therapeutic implications:
- estrogen receptor (ER)
- progesterone receptor (PR)
- human epidermal growth factor receptor 2 (HER2; protooncogene Neu; receptor tyrosine-protein kinase erbB-2)
Staging
Staging of breast tumors is performed according to the TNM system published by the American Joint Committee on Cancer (AJCC)/Union for International Cancer Control (UICC): breast cancer (staging).
Radiographic appearance
Dedicated evaluation of the breast involves multiple imaging modalities to detect and localize lesions for biopsy. In all modalities, regional metastasis can be suspected by the presence of axillary adenopathy.
Mammography
Neoplasms have varied appearances, including masses, asymmetries, calcifications, or architectural distortions.
Ultrasound
Neoplasms can appear as masses or architectural distortions. Calcifications can sometimes be seen.
MRI
Neoplasms can manifest as masses with or without enhancement, nonmass enhancement, or foci of enhancement.
CT
Breast masses may be incidentally identified but CT is not the preferred modality for dedicated breast evaluation. If calcifications are visualized on CT, they are nearly all benign .
Radiology report
The use of a standard lexicon is recommended to enhance communication with referrers and audit performance: breast imaging-reporting and data system (BI-RADS).
Siehe auch:
- invasives lobuläres Karzinom
- breast lumps
- Metastasen bei Mammakarzinom
- intraductales Papillom der Mamma
- Morbus Paget der Mamille
- Fibromatose der Mamma
- Sarkom der Mamma
- Mammakarzinom beim Mann
- artifacts that mimic breast calcification
- fibrosarcoma of the breast
- inflammatorisches Mammakarzinom
- Lymphom der Mamma
- Granularzelltumor der Mamma
- adenoid cystic carcinoma of the breast
- tubular carcinoma of breast
- lobular carcinoma in situ (LCIS)
- Liposarkom der Mamma
- apocrine carcinoma of the breast
- komplizierte Zyste Mamma
- duktales in situ Karzinom der Mamma
- Malignitätskriterien Sonographie Mamma
- tubulolobular carcinoma of breast
- breast cancer staging
- extraskelettales Osteosarkom der Mamma
- Phylloidestumor
- Mammakarzinom Sonographie
- medullary breast carcinoma
- comedo type
- metastasis to the breast
- metaplastic carcinoma of the breast
- Angiosarkom der Mamma
- breast screening
- Atypische duktale Hyperplasie (ADH)
- terminal duct lobular unit (TDLU)
- papilläres Mammakarzinom
- metastasis(es) to breast
- papilläre Neoplasien der Mamma
- invasives muzinöses Mammakarzinom
- atypische lobuläre Hyperplasie (ALH)
- Nicht-Komedo duktales in situ Karzinom der Mamma
- Juvenile Papillomatose der Mamma
- maligner Phylloidestumor
und weiter:
- Tumoren der Schädelkalotte
- osteoblastische Knochenmetastasen
- solitäre lytische Läsion des Schädels
- Kerley-Linien
- cancer
- breast curriculum
- miliare Lungenherde
- tree in bud-Muster
- Metastasen in der Orbita
- bilaterale axilläre Lymphadenopathie
- Superscan Szintigraphie
- breast ultrasound
- hyperdenser Lymphknoten
- metastases to the pituitary gland
- Mondor disease
- ultrasound appearances of liver metastases
- chronische abakterielle Mastitis
- Krukenberg-Tumor
- ivory vertebra sign
- differential diagnosis of unilateral axillary lymphadenopathy
- Somatostatin-Rezeptor-Szintigrafie
- miliary nodules in the exam
- diabetische Mastopathie
- tubular carcinoma of the breast
- FIGO-Klassifikation
- hyperechoic breast lesions
- einfache Zyste Mamma
- fibroadenomatoid mastopathy
- microglandular adenosis of the breast
- metastatic axillary lymphadenopathy of unknown primary
- architectural distortion in mammography
- breast screening programmes
- asymmetrical density in mammography
- metastases to the cervix
- Cowden-Syndrom
- differential diagnosis of calcific axillary lymphadenopathy
- LCIS
- Brachytherapie
- Galaktozele
- postoperative Narben Mamma
- medullary carcinoma of the breast
- lobular breast carcinoma
- triple receptor negative breast cancer
- ductal adenoma of breast
- pregnancy associated breast cancer
- intracystic papillary carcinoma of the breast
- verkalkte Metastasen
- multi-focal breast cancer
- bilateral lobular carcinoma of the breast
- differential diagnosis of dilated ducts on breast imaging
- breast self-examination
- differential diagnosis of dilated mammary veins
- multi-centric breast cancer
- Mammakarzinom in einer Zyste
- Abszess der Mamma
- Brustdichte in der Mammographie
- gemischt osteolytisch osteoblastische Knochenmetastasen
- idiopathische granulomatöse Mastitis
- Senologie
- granulomatöse Mastitiden allgemein
- scirrhous carcinoma of the breast
- eingeblutete Metastasen
- sklerosierende Adenose der Mamma
- radiäre Narbe der Mamma
- hyperdense pulmonale Raumforderungen
- Lungenmetastasen bei Mammakarzinom