DTPA
Tc-99m DTPA (diethylene-triamine-pentaacetate) is one of the technetium radiopharmaceuticals used in renal imaging and primarily used to measure the glomerular filtration rate (GFR).
Characteristics
- photon energy: 140 KeV
- physical half-life: 6 hours
- biological half-life: 2.5 hours
- normal distribution: kidneys (100%)
- pharmacokinetics
- uptake by glomerular filtration (100%)
- first pass filtration: 10-20%
- excretion: renal; cleared only via glomeruli with no tubular excretion. Thus making it available for direct measurement of GFR.
- target organ: bladder
- miscellaneous facts:
- poor quality images with renal insufficiency
Uses, doses and timings
- renal study
- adult dose: 555 MBq (15 mCi) IV
- 60 sec flow study; then every 5 minutes for 25 minutes
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- 2-hydroxyglutarate peak: resonates at 2.25 ppm
- alanine peak: resonates at 1.48 ppm
- choline peak: resonates at 3.2 ppm
- citrate peak: resonates at 2.6 ppm
- creatine peak: resonates at 3.0 ppm
- functional MRI (fMRI)
- gamma-aminobutyric acid (GABA) peak: resonates at 2.2-2.4 ppm
- glutamine-glutamate peak: resonates at 2.2-2.4 ppm
- Hunter's angle
- lactate peak: resonates at 1.3 ppm
- lipids peak: resonates at 1.3 ppm
- myoinositol peak: resonates at 3.5 ppm
- MR fingerprinting
- N-acetylaspartate (NAA) peak: resonates at 2.0 ppm
- propylene glycol peak: resonates at 1.13 ppm
- MRI artifacts
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- central point artifact
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- Tc-99m DMSA
- Tc-99m DTPA
- Tc-99m DTPA aerosol
- Tc-99m HMPAO
- Tc-99m HMPAO labeled WBC
- Tc-99m MAA
- Tc-99m MAG3
- Tc-99m MDP
- Tc-99m mercaptoacetyltriglycine
- Tc-99m pertechnetate
- Tc-99m labeled RBC
- Tc-99m sestamibi
- Tc-99m sulfur colloid
- Tc-99m sulfur colloid (oral)
- thallium-201 chloride
- xenon agents
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- erbium-169
- samarium-153
- strontium-89
- yttrium-90
- pharmaceuticals used in nuclear medicine
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